China on Monday said it will strive with utmost sincerity for the peaceful reunification of Taiwan and not tolerate any activities aimed at splitting the country, in an angry response to President Joe Biden's remarks that the US forces would defend Taiwan if Beijing tries to invade the self-ruled island.

Biden said yes when asked during an interview broadcast on Sunday on CBS News's 60 Minutes programme whether US forces, US men and women, would defend Taiwan in the event of a Chinese invasion."

The White House has been quick to downplay Biden's previous comments on Taiwan, reiterating that the US policy hasn't changed.

This is the second time since May this year that Biden has replied affirmatively to questions on the US militarily intervening to defend Taiwan's independence, adding a military dimension to Washington's Taiwan policy much to the chagrin of Beijing.

While visiting Japan in May, Biden said America will stand with Japan and other nations to not let China forcibly take over Taiwan.

When asked at a press conference in Tokyo if the US is willing to get involved militarily to defend Taiwan, Biden said yes.

That is the commitment we made. Here is the situation: we agree with the One China policy. We signed on to it and all the attendant agreements made from there.

But the idea that it can be taken by force is just not appropriate, it will dislocate the entire region and be another action similar to what happened in Ukraine. So, it is a burden that is even stronger, he said, likening Taiwan's issue to that of Russia's invasion of Ukraine.

Reacting to Biden's interview with CBS News, Chinese Foreign Ministry spokesperson Mao Ning on Monday said the US leader's remarks seriously violated the 'one China' policy and three joint communiques related to Taiwan.

Biden's remarks seriously breached the US commitment of not supporting Taiwan's independence and sent an erroneous signal to Taiwan's independence forces, Mao said.

China deplores and firmly opposes that and we have launched several representations, to the US, she said.

There is only one China and Taiwan is part of it and the People's Republic of China (PRC) government is the sole government representing the entire China, Mao said.

To achieve the complete unification of the motherland is the shared aspiration and sacred duty of all Chinese people, she said.

We will strive for the prospect of a peaceful reunification with utmost sincerity and efforts. In the meantime, we will not tolerate any activities that are aimed to split China and we reserve all options of taking the necessary measures, Mao said.

Nobody should understate our resolve, will and capability to defend our sovereignty and territorial integrity. They should not stand on the opposite side of the 1.4 billion Chinese people, she said.

We urge the US to fully understand the extremely important and the highly sensitive nature of the Taiwan question and abide by the 'one China' principle and three joint communiques, earnestly implement the US leadership commitment of not supporting Taiwan's independence, she said.

The US should prudently and properly handle the Taiwan-related issues and refrain from sending an erroneous signal to Taiwan independence forces so as to prevent further damage to China-US relations and peace and stability along the Taiwan Strait, she said.

The US-China differences over the Taiwan issue in recent months have escalated after US House Speaker Nancy Pelosi visited Taipei, becoming the first top American official to visit the self-ruled island in 25 years.

Besides the diplomatic protest, China went ballistic over her visit launching massive air, naval and missile drills close to Twain for over a week in August, sparking concerns that Beijing was preparing for an invasion of the island.

Biden's comments that the US was not averse to using force effectively jeopardises Chinese leader Xi Jinping's vocal plan of national integration.

Taiwan's integration with the Chinese mainland is the major political plank of Xi, who is widely expected to be endorsed for an unprecedented third term in power in next month's once- in-a-five-year-congress of the ruling Communist Party of China, (CPC).

All his predecessors retired after two terms and Xi, 69, is declared the core leader of the party, a status enjoyed by party founder Mao Zedong.

He is widely expected to continue in power perhaps for life as there is no visible challenge to his leadership.

So far, successive US administrations maintained what was officially termed as strategic ambiguity of tacitly backing Taiwan while publicly asserting commitment to the One China policy, but Biden is adding a new dimension to it in the backdrop of Russia's invasion of Ukraine.