The coronavirus outbreak in China may be over by April, its senior medical adviser said on Tuesday, but deaths passed 1,000 and the WHO feared a “very grave” global threat.

As the epidemic squeezed the world’s second-biggest economy, Chinese firms struggled to get back to work after the extended Lunar New Year holiday, hundreds of them saying they would need loans running into billions of dollars to stay afloat.

Company layoffs were beginning despite assurances by President Xi Jinping that widespread sackings would be avoided, as supply chains for global firms from car manufacturers to smartphone makers ruptured.

China’s foremost medical adviser on the outbreak, Zhong Nanshan, told Reuters numbers of new cases were falling in parts and forecast the epidemic would peak this month.

“I hope this outbreak or this event may be over in something like April,” added Zhong, 83, an epidemiologist who won fame for his role in combating an outbreak of Severe Acute Respiratory Syndrome in 2003.

The WHO said on Tuesday 1,017 people had died in China where there were 42,708 cases.

Only 319 cases have been confirmed in 24 other countries and territories outside mainland China, with two deaths: one in Hong Kong and the other in the Philippines.

World stocks, which had seen rounds of selloffs due to the coronarivus’ impact on China’s economy and ripple effects round the world, kept rising towards record highs on Zhong’s comments.

WHO chief Tedros Adhanom Ghebreyesus was less sanguine, however, appealing for the sharing of virus samples and speeding up of research into drugs and vaccines.

“With 99 per cent of cases in China, this remains very much an emergency for that country, but one that holds a very grave threat for the rest of the world,” he told researchers in Geneva.

With travel curbs, lockdowns and production suspensions all affecting China’s economy, many were trying to calculate and predict the probable impact.

JPMorgan analysts downgraded forecasts for Chinese growth this quarter, saying the outbreak had “completely changed the dynamics” of its economy.

Investment bank Nomura's analysts said the virus seemed to have had “a devastating impact” on China’s economy in January and February and markets “appear

to be significantly underestimating the extent of disruption”.

Norway’s biggest independent energy consultancy Rystad Energy predicted the outbreak will cut growth in global oil demand by a quarter this year.

However, two EU officials said the impact on the bloc from damage to China’s economy would only be “marginal”.

Inside China, more than 300 companies are seeking bank loans totalling 57.4 billion yuan ($8.2 billion) to help cope with the disruption, banking sources said.

Prospective borrowers include food delivery giant Meituan Dianping, smartphone maker Xiaomi Corp and ride-hailing provider Didi Chuxing Technology Co.

Chinese firm Xinchao Media said on Monday it had laid off 500 people, or just over a tenth of its workforce, and restaurant chain Xibei said it was worried about how to pay its 20,000 workers.