A powerful 6.6-magnitude earthquake in west Nepal rocked the Himalayan nation in the early hours of Wednesday, killing at least 6 people and injuring five.

According to the National Seismological Centre, the earthquake occurred at 2:12 am with its epicentre at Khaptad National Park in the Doti district.

Six persons have been killed in the earthquake, Home Ministry spokesperson Phanindra Pokharel said.

Five persons who sustained serious injuries have been rushed to the district hospital in Doti, Pokharel told PTI over the phone. A police post and eight houses collapsed due to the earthquake.

Deputy Superintendent of Police Bhola Bhatta, the acting chief at the District Police Office in Doti, said that all the victims were killed by the debris of the houses damaged during the earthquake.

Nepal Army and Nepal Police personnel have been mobilised to carry out rescue operations.

Nepal's Prime Minister Sher Bahadur Deuba was also in Western Nepal for an election campaign when the earthquakes hit the region. He was attending election rallies and meeting people at Dhangadhi district, 160 km South of the epicentre.

The tremor was also felt in Dhangadhi though the Prime Minister is safe, according to Pokharel.

Adjustments will be made regarding the election campaign of the Prime Minister in Western Nepal keeping in mind the incident, he added.

According to Nepal Army spokesperson Narayan Silwal three persons were missing and are believed to have been trapped in the housing collapse in Purvichauki. The Nepal Army has started searching for the missing persons, he added.

The tremors were also felt in neighbouring Dhangadhi and Kailali districts.

The earthquake that was felt mildly in Kathmandu and parts of India has also caused damage to dozens of other houses in the district.

Earlier, a 5.7-magnitude tremor was recorded at 9.07 pm and another 4.1-magnitude tremor at 9.56 pm on Tuesday at the same epicentre, according to the Seismological Centre.

In April 2015, a devastating earthquake of 7.8-magnitude rocked Nepal, killing nearly 9,000 people and wounding nearly 22,000 others. It also damaged over 800,000 houses and school buildings.