Russia targeted the Ukrainian capital, Kyiv, yet again in the early hours of Thursday, killing three people, including at least one child, officials said. Air raid sirens and loud explosions throughout the city awoke residents worn out by a month of relentless attacks.

Kyiv’s mayor, Vitali Klitschko, said on the Telegram messaging app that an additional 16 people were injured by debris from air defence systems shooting down incoming attacks. Ukraine’s general staff headquarters said Kyiv had been attacked by a volley of 10 Iskander ballistic missiles, all of which were shot down.

The city’s military administration said some of the debris fell on a children’s clinic and an adjacent building. A mother and child were killed trying to get into a shelter at the clinic that was locked, according to Klitschko and two emergency workers at the scene who declined to be named.

City officials opened a criminal investigation into the clinic and the administrators responsible for operating the shelter there, centred on whether the shelter was properly maintained and why it may have been inaccessible, Klitschko said.

It was yet another night that Kyiv’s 3.6 million residents were jolted out of bed and sent scurrying for cover. The overnight attack early on Thursday left very little time for residents to take shelter, with air defences colliding with missiles just six minutes after the alarm sounded, the Kyiv administration said.