Russia launched its second large salvo of missiles at Ukraine in recent days early Monday, damaging buildings and wounding at least 34 people in the eastern city of Pavlohrad but failing to hit Kyiv, officials said.

Air raid sirens began blaring across the capital at about 3:45 a.m., followed by the sounds of explosions as missiles were intercepted by Ukrainian defence systems.

Eighteen cruise missiles were fired in total from the Murmansk region and the Caspian region, and 15 of them were intercepted, said Ukrainian Armed Forces Commander-in-Chief Valerii Zaluzhnyi.

The head of Kyiv's city administration, Serhii Popko, said all missiles fired at the city were shot down, as well as some drones. He didn't provide further details, but said more information would be available later.

The attack follows Friday's launch of more than 20 cruise missiles and two explosive drones at Ukraine, which was the first to target Kyiv in nearly two months.

In that attack, Russian missiles hit an apartment building in Uman, a city about 215 kilometres (135 miles) south of Kyiv, killing 21 people including three children.

In Monday's attack, missiles hit Pavlohrad, in the eastern Dnipropetrovsk region, wounding 34 people, including five children, according to Serhii Lysak the region's top official.

Seven missiles shot at the city and "some were intercepted" but others hit an industrial facility, sparking a fire, and a residential neighbourhood where 19 apartment buildings, 25 homes, six schools and five shops were damaged, he said.

Missiles also hit three other areas in the region, damaging residential buildings and a school, he said.

Moscow has frequently launched long-range missile attacks during the 14-month war, often indiscriminately hitting civilian areas.

Ukraine has recently taken delivery of American-made Patriot missiles, providing improved anti-missile defences, but it was not clear whether any of them were employed in trying to stop Monday morning's attack.

Ukraine has also been building up its mechanised brigades with armour supplied by its Western allies, who have also been training Ukrainian troops and sending ammunition, as Kyiv prepares for an expected counteroffensive this spring.

On Saturday, two Ukrainian drones hit a Russian oil depot in Crimea in the latest attack on the annexed peninsula as Ukraine gears up for for its counteroffensive.

Ukrainian President Volodymyr Zelenskyy said in an interview last week that his country would seek to reclaim the peninsula annexed by Russia in 2014 in the upcoming counteroffensive.