The European Parliament gave final approval to Britain’s divorce from the EU on Wednesday, paving the way for the country to quit the bloc on Friday after nearly half a century and delivering a major setback for European integration.

After an emotional debate during which several speakers shed tears, EU lawmakers voted 621 for and 49 against the Brexit agreement sealed between Britain and the 27 other member states last October, more than three years since Britons voted out.

Thirteen lawmakers abstained and the chamber then broke into a rendition of Auld Lang Syne, a traditional Scottish folk song of farewell. Britain’s 73 departing EU lawmakers headed for an “Au Revoir” party in the EU chamber after the vote.

Earlier on Wednesday, Britain’s ambassador to the EU handed documents formalising Brexit to a senior EU official. Against a backdrop of British and EU flags at the bloc’s Brussels headquarters, Tim Barrow, smiling, passed over a dark blue leather file embossed with the emblem of the UK.

After protracted divorce talks, Britain will leave the club it joined in 1973 at midnight Brussels time (2300 GMT) on Friday, when British flags will be removed from EU offices and the EU flag lowered on the British premises there.

With a status-quo transition period running only until year-end, fresh talks — covering everything from trade to security — will begin soon on a new relationship.

“We are considering a zero-tariff, zero-quotas free trade agreement. But the precondition is that EU and British businesses continue to compete on a level playing field,” European Commission head Ursula von der Leyen told the chamber.