Comments Donald Trump's running mate JD Vance made in 2021 questioning Vice President Kamala Harris' leadership because she did not have biological children have resurfaced, testing the young conservative senator in his early days campaigning as part of Republicans' presidential ticket.

During Vance's bid for the Senate from Ohio, he said in a Fox News interview that “we are effectively run in this country via the Democrats," and referred to them as "a bunch of childless cat ladies who are miserable at their own lives and the choices that they've made and so they want to make the rest of the country miserable, too." He said that included Harris, U.S. Transportation Secretary Pete Buttigieg and U.S. Rep. Alexandria Ocasio-Cortez, a New York Democrat.

“How does it make any sense that we've turned our country over to people who don't really have a direct stake in it?" Vance asked. Harris became stepmother to two teenagers when she married entertainment lawyer Douglas Emhoff in 2014.

The clip has started to spread online, with Hillary Clinton sharing it in a Tuesday post on X and adding sarcastically “what a normal, relatable guy who certainly doesn't hate women having freedoms.”

The Trump campaign did not respond to a request for comment. The Harris campaign contested Vance's stance, saying “every single American has a stake in this country's future.” “Ugly, personal attacks from JD Vance and Donald Trump are in line with their dangerous Project 2025 agenda to ban abortion, decimate our democracy, and gut Social Security,” said James Singer, a Harris campaign spokesman, referring to a policy and personnel plan for a second Trump term that was crafted by a host of former administration officials. Trump has been trying to distance himself from it.

The recirculated comment may be a sign of the ticket's troubles appealing to women voters, and on the issue of reproductive rights. It follows the explosive entrance in the race of Harris, who secured the support of enough delegates to become the official nominee in less than 32 hours after President Joe Biden ended his reelection bid.

It also lays out some of the fears expressed by strategists that Trump took a political risk in picking a running mate who has been in Congress less than two years and is largely untested on a bigger stage. Trump liked Vance's telegenic qualities and said he reminded him of “a young Abraham Lincoln.”

Vance, 39, is a former Marine and businessman who was first elected to public office in 2022. He wrote the 2016 bestseller “Hillbilly Elegy,” and developed a strong rapport with Trump, his son Donald Trump Jr. and leading MAGA figures with his personal story of growing up in Appalachia in poverty with a mother battling drug addiction could resonate with voters.

One of the major questions Vance is facing is on his abortion stance. Vance previously said he would support a national abortion ban at 15 weeks of pregnancy.

In 2021, Vance floated an idea to allow parents to cast ballots on behalf of their children, saying during a speech at the conservative nonprofit Intercollegiate Studies Institute in Virginia that people who don't have children “don't have as much of an investment in the future of the country.”

“When you go to the polls in this country as a parent, you should have more power, you should have more of an availability to speak your voice in our democratic republic than people who don't have kids,” he said.

“Doesn't this mean that non parents don't have as much of a voice as parents?” he said critics would then ask. “Doesn't this mean that parents get a bigger say in how a democracy functions? Yes, absolutely.”