China on Thursday replaced its top officials in the central province of Hubei and its capital, Wuhan, the epicenter of a viral outbreak that has infected more than 45,000 people worldwide.

Former Shanghai Mayor Ying Yong succeeds Jiang Chaoliang as the ruling Communist Party's chief in the beleaguered province, the Xinhua state news agency reported, while Wang Zhonglin will take over from Ma Guoqiang as the party secretary in Wuhan.

The high-level appointments follow the sacking earlier this week of two leaders of the provincial health commission. State media also reported that a slew of others were expelled from the party for transgressions related to the epidemic.

The public has widely criticized local officials for their handling of the outbreak of a new form of coronavirus. The virus first surfaced December in Hubei's capital, Wuhan, and has since spread to more than two dozen countries.

Many countries have implemented travel restrictions on recent visitors to China, which has more than 99% of the world’s reported infections.

In Vietnam, official media reported that a commune of 10,000 residents northwest of the capital Hanoi was put in lockdown due to a cluster of cases there.

The online newspaper VN Express cited a senior official of Vinh Phuc province as reporting an increase in cases in Son Loi commune. Vietnam has confirmed 16 case of the diseases, most of them in the province.

In an unprecedented measure to contain the disease, recently dubbed COVID-19, the Chinese government has placed the hardest-hit cities — home to more than 60 million — under lockdown.

Japan’s Health Ministry announced Thursday that 44 more people on a cruise ship quarantined in the port of Yokohama, near Tokyo, have tested positive for COVID-19. The ship has 218 infections among its 3,700 passengers and crew.

Health Minister Katsunobu Kato told reporters five of the patients who were already sent to hospitals for isolation and treatment of COVID-19 have severe symptoms and are on artificial respirators or under intensive care.

Another cruise ship, the Westerdam, finally anchored Thursday off Cambodia after being turned away by several Asian and Pacific governments. No cases of the viral illness have been confirmed among its 1,455 passengers and 802 crew members, according to operator Holland America Line.

Thailand refused to allow the Westerdam to dock this week after it had already been turned away by the Philippines, Taiwan, Japan and Guam over virus concerns.

The Westerdam began its cruise in Singapore last month and its last stop before it was refused further landings was in Hong Kong, where 50 cases of the viral disease have been confirmed.