Actor Soumitra Chatterjee was put on life support on Saturday as his condition remained critical on Saturday, officials said.
The actor, who was admitted there over a month ago, remained in the same condition for the last 24 hours, a doctor attending him said.
"He is on different life support systems ... It seems that our almost 40 days' fight is not enough to make him well," he said.
"Let's all pray he gets better, but it seems unlikely he will have a favourable outcome. We have informed all the family members and with a saddened heart they have accepted that nothing less than miracle can get him out of this situation," a bulletin released by the doctor says.
"His situation is really grave and critical,” the doctor informed, adding that the 85-year-old has seemingly not responded to ongoing therapies.
An EEG has shown that there is very little activity in the brain, the doctor said on Friday.
He had added that the thespian’s oxygenation level had gone up and his kidneys were not functioning well.
Chatterjee had received plasmapheresis on Thursday and tracheostomy on Wednesday.
The legendary actor, who debuted in Satyajit Ray's masterpiece "Apur Sansar", has been under treatment in the hospital since October 6 after testing positive for COVID-19.
He later tested negative for the infection but Covid- 19 encephalopathy set in and various other complications surfaced.