World No.3 Stefanos Tsitsipas was defiant as his grand slam hopes evaporated on Friday, saying “everyone suddenly is against me” and insisting he was innocent of wrongdoing in a bitter bathroom-break saga at the US Open.

The Greek unwillingly assumed the role of tournament villain at Flushing Meadows when Briton Andy Murray accused him of cheating over a lengthy trip to the bathroom at a critical point in their first-round match. Tsitsipas insisted he hadn’t broken any rules.

“I’m not pretending that everyone loves me,” he said.

The debate over toilet breaks finally closed out in dramatic fashion as 18-year-old Spaniard Carlos Alcaraz handed Tsitsipas a shock 6-3, 4-6, 7-6 (2), 0-6, 7-6 (5) defeat and the rowdy New York crowd again booed him for stepping into the locker room at a crucial point in the match.

“I took my toilet break as a normal athlete,” Tsitsipas said afterwards, adding that he had only changed from wet clothes to dry ones.

In another match, American Frances Tiafoe upset fifth seed Andrey Rublev 4-6, 6-3,7-6 (6), 4-6, 6-1 to move into the fourth round.

In the women’s third round on Saturday, former US Open champion Bianca Andreescu fired off 21 winners to make quick work of Belgian Greet Minnen for a 6-1, 6-2 win. The Canadian will next meet French Open semi-finalist Maria Sakkari, who beat two-time Wimbledon champion Petra Kvitova 6-4, 6-3.