Manchester United will face former coach José Mourinho's new club Fenerbahce among their eight opponents drawn on Friday in the new format of the Europa League.
Mourinho led Manchester United to win the Europa League in 2017 during his two-and-a-half years at Old Trafford and took the Fenerbahce job in the offseason.
The date of the game in Istanbul will be confirmed by the Union of European Football Associations on Saturday. The competition starts on September 25, a week after the Champions League opens.
As in the Champions League, the traditional group stage of the Europa League has been abolished and replaced with an expanded league phase with all 36 teams competing in a single standings.
United will host Rangers, PAOK, Bodo/Glimt and Twente, and also travel to Porto, Viktoria Plzen and FCSB, the club known as Steaua Bucharest when they won the 1986 European Cup.
United avoided being paired with Ajax, the former club of their coach Erik ten Hag and the team they beat in the 2017 final.
Fenerbahce will also host Lyon and Athletic Bilbao but Mourinho avoided the two previous clubs he coached, Tottenham Hotspur and Roma.
Tottenham's eight games include hosting Roma, travelling to Glasgow to face anger and to Istanbul to face Galatasaray.