The Copa America is down to the final four with a pair of fascinating semi-finals and favourites Argentina hoping they can win their third straight major title.

The Argentines, world champions and defending Copa title holders, open the semi-final action when they face surprise package Canada on Tuesday in New Jersey.

Then on Wednesday in Charlotte, Uruguay — who knocked out Brazil after a shoot-out on Saturday — will play a Colombia team which, unbeaten in 27 games, beat Panama 5-0 in their quarter-final.

Argentina and Uruguay, currently tied for 15 Copa America titles, are both hoping they can break that deadlock to become the most successful nation in the tournament's history.

Colombia have a solitary title from 2001 while Canada are playing in the tournament for the first time.

Argentina needed penalty shoot-out heroics from their goalkeeper Emiliano Martinez to get past Ecuador in the last eight and while Lionel Scaloni's team have yet to really hit top gear they start as clear favourites against Canada.

The only cause for concern for Argentina is that their captain, Lionel Messi is yet to score at the tournament. The Inter Miami forward has generated 0.85 expected goals and 1.3 shots on target per game whilst providing one assist so far. Lisandro Martinez is the leading goalscorer at the tournament with four to his name.

American coach Jesse Marsch has made an instant impact with Canada, taking over in mid-May and quickly implementing his high-energy, pressing style to great effect.

Marsch, who was reported to be close to taking over as the US coach before the decision last year to re-hire Gregg Berhalter, has had the last laugh as his team has produced a memorable run to the last four while the Americans failed to get out of their group.

Canada got past a Venezuela team that had won all three of their group-stage games, winning on penalties at the end of a pulsating encounter on Friday.

However, they know that Messi and Argentina represent a different proposition.

The teams met in the opening group game of the tournament with Argentina winning 2-0, but there is no shortage of confidence in Marsch's team.

"It's going to take everything," said Bayern Munich wing-back Alphonso Davies.

"Going into this game, we know what's on the line. We win and go forward, we lose and go home. They're going to come out with everything. We're hungrier than ever, we expect a battle — as they should," he said.

Three of the four quarter-finals were decided on penalties, but Marsch insists his team will play their usual attacking style.

"The game against Argentina will have to be the best we've ever played... We're not going to sit back and just try to defend. We will be aggressive. We're going to try to play the way we want to play and see if we can keep it up," he promised.

Argentina's line-up remains largely the one which triumphed in Qatar in 2022.