Paraguay held Uruguay to a goalless draw in their South American World Cup qualifier on Friday, with striker Luis Suarez bringing his 17-year international career to an end at the Centenario stadium in Montevideo.
The 37-year-old forward reached 143 appearances for his country, finishing as their all-time leading scorer with 69 goals.
Marcelo Bielsa's side, who finished third in the Copa America, played without five players from their starting line-up, including Darwin Nunez, who were suspended for their involvement in clashes with fans following the defeat to Colombia in the continental showpiece in July.
Uruguay wasted several chances, most notably a first-half right-footed volley from Suarez that struck the post after Facundo Pellistri's cross.
Paraguay also created clear-cut opportunities, with Miguel Almiron coming closest only to be denied by goalkeeper Sergio Rochet, but neither side managed to capitalise.
Uruguay remain second in the World Cup qualifying standings on 14 points, four behind leaders Argentina. They face Venezuela on Tuesday, while Paraguay take on Brazil.