Genetic Research

BHU scientist’s research on fingerprint patterns finds place in CELL

Our Correspondent
Our Correspondent
Posted on 11 Jan 2022
19:47 PM
Chandana Basu earlier had received fellowship of Rs 1.67 crore for her study on the genetics behind human hair.

Chandana Basu earlier had received fellowship of Rs 1.67 crore for her study on the genetics behind human hair. Source: BHU

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Summary
The study was conducted by a team of international scientists comprising those from Shanghai, Australia, UK, USA, and India
Chandana Basu, scientist from Centre for Genetic Disorders, Institute of Science, is the only scientist from India on the team

Chandana Basu, a scientist from Banaras Hindu University, and other scientists have been researching the genes responsible for fingerprint patterns in humans. Recently, the study has been published in the CELL—one of the most prestigious scientific journals of Science.

The study was conducted by a team of international scientists comprising those from Shanghai, Australia, UK, USA, and India. Basu, Scientist from Centre for Genetic Disorders, Institute of Science, was the only scientist from India in the team.

Fingerprints are known to be unique to an individual but they can be generally categorized into three types – arch, loop, and whorl. To understand the genes responsible for fingerprint patterning, the team studied DNA from more than 23,000 individuals from different ethnic groups and identified 43 genetic loci contributing to fingerprint patterning. Interestingly, they found that most of these genetic loci are from the genes involved in the limb development pathways rather than genes related to skin development.

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One of the topmost genes identified was EVI1, which has been known for its role in embryonic limb development. When the team further tested using mouse models of EVI1, they found that genetically modified mice with decreased expression of EVI1 developed abnormal skin patterns on their digits compared to the wild-type normal mice. Furthermore, the study also revealed the correlation of fingerprint patterns with hand proportions. For example, people with whorl-shaped fingerprints on both their little fingers tend to have longer little fingers than those who don’t. This is one of the most comprehensive studies on genetics of fingerprints patterns and studies like these help us to better understand the existing human phenotypes or how we vary from each other.

Basu says, “There are no fingerprints in mice, but it was interesting to develop a method of scoring the ridges (the analogue of fingerprints). When we compared these ridge patterns between modified EVI1 and normal mice, we found a similar result as humans.” This is one most comprehensive study on genetics of fingerprint patterns.

Parimal Das, coordinator of Centre for Genetic Disorders, said, “Comprehensive studies like these involving population genetics, mice model, cell biology, protein network is a powerful approach to unravel the biology of complex traits and is the need of the hour.”

Last updated on 12 Jan 2022
09:34 AM
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